|
KMID : 0043320060290060469
|
|
Archives of Pharmacal Research
2006 Volume.29 No. 6 p.469 ~ p.475
|
|
|
Synthesis and Evaluation of Biological Properties of Benzylideneacetophenone Derivatives
|
|
Oh Sei-Kwan
Jang So-Yong
Kim Dong-Hyun
Han Inn-Oc
Jung Jae-Chul
|
|
|
Abstract
|
|
|
|
A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS.induced NO generation, and cytotoxicity in microglia.
|
|
|
KEYWORD
|
|
|
Benzylideneacetophenones, Synthesis, Grignard reaction, NO generation, Freeradical scavenging, Cytotoxicity, Anti-excitotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|